阿尔茨海默病患者海马结构的断层影像学研究

doi:10.13418/j.issn.1001-165x.2020.01.007

Abstract

Abstract: Objective　To observe the morphological changes on sectional imaging of the hippocampal formation (HPF) in patients in the process of alzheimer's disease (AD).　Methods　According to the pathogenesis of AD, 34 cases of a normal control (NC) group, 34 cases of a mild cognitive impairment (MCI) group, 34 cases of an AD group, which a total of 102 cases were collected, with 17 cases of male and 17 cases of female in each group respectively. The hippocampal area, the transverse diameter, the sagittal diameter and the temporal lobe hook gyrus spacing, the temporal horn width were measured. The change trend of the measured values among the groups and the correlation between the hippocampal area and the scores of the neural rating scale were analyzed.　Results　There was no statistical difference of hippocampal area in the three groups. Compared with the measured values among the groups, the hippocampal area of the AD group was smaller than that of the NC group and the MCI group (P<0.05).The hippocampal transverse diameter of the AD group was smaller than that of the NC group and the MCI group, and the hippocampal transverse diameter of the MCI group was smaller than that of the NC group (all P<0.01). In AD group, the temporal lobe hook gyrus spacing was greater than that in the NC group and the MCI group (all P<0.01), and in MCI group, the temporal lobe hook gyrus spacing was greater than that in the NC group (P<0.05). Hippocampal area and hippocampal transverse diameter were negatively correlated with clinical dementia scale (CDR) and Hamilton depression scale (HAMD) scores, and positively correlated with Montreal cognitive assessment scale (MoCA) scores；the correlation between the distance of temporal lobe hook gyrus and the score of neuropsychological scale scores was opposite to that of hippocampal area and hippocampal transverse diameter.　Conclusions　With the progression of AD, the hippocampal area and hippocampal transverse diameter gradually decrease, while the temporal lobe hook gyrus spacing gradually increase. Changes in the hippocampus can damage its cognitive function.

Key words: AD, 　Hippocampal formation, 　MRI

CLC Number:

R322.81

BAI Gui-qin, XIAO Ru-hui, CHEN Li, HUANG Xiao-hua, YANG Zheng-wei, CAI Chang-ping. Sectional imaging study of the hippocampus in patients with alzheimer's disease[J]. Chinese Journal of Clinical Anatomy, 2020, 38(1): 29-34.

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Sectional imaging study of the hippocampus in patients with alzheimer's disease

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