Abstract: Objective　To investigate the clinical effects of oblique lateral interbody fusion (OLIF) combined with cortical bone trajectory (CBT) screws internal fixation in the treatment of lumbar degenerative diseases.　Methods　32 cases with lumbar degenerative diseases were treated with OLIF and CBT screws fixation from April 2016 to April 2018. A retrospective analysis was performed to observe the operation time, intraoperative blood loss, complications, intervertebral height, intervertebral fusion time. The visual analogue scale (VAS), low back pain in patients with Oswestry disability index (ODI) were used to evaluate the clinical effect.　Results　All cases were followed up for 1-2 years, with an average of 1 year. There were 25 cases of single segment, 5 cases of two segments, 2 were adjacent segment disease after lumbar degeneration surgery, 13 male and 19 female in the 32 patients. There were statistical differences in the height of intervertebral recovery, lumbar anterior angle and lateral curvature correction angle between after operation and those of before operation (P<0.05).The intervertebral fusion time was 3.2±1.3 months, and the VAS score of lumbar and leg pain decreased from the preoperative average score (6.5±2.8) to (2.5±1.7) post-operation, (P<0.05).The ODI index decreased from (48.7±19.7) % pre-operation to (15.2±9.6) % post-operation (P<0.05).　Conclusions　OLIF combined with CBT internal fixation for the treatment of lumbar degenerative diseases is effective, with minimally invasive and few complications. It has significant clinical effect for the treatment for osteoporosis and adjacent segment disease surgery, and it is worthy in clinical application.

Key words:  , OLIF, 　CBT, 　ASD, 　Osteoporosis