Abstract: Objective　To investigate the clinical diagnosis and treatment strategy of deep cerebral venous thrombosis (DCVT).　 Methods　A total of 5 DCVT patients were enrolled during the past 10 years. The clinical manifestations, imaging features, treatment and prognosis were retrospectively analyzed.　Results　DCVT commonly was involved in the internal cerebral veins, vein of Galen, straight sinus, or basal vein of Rosenthal. However, the clinical manifestations of DCVT were atypical. Among patients seen in neurology clinics, headache, disturbance of consciousness, diplopia, and hemiplegia were common manifestations. Oral contraceptives, pregnancy, and puerperium were the common risk factors. Thalamic lesions were the common radiologic sign of DCVT. Heparin offered a simple and effective therapy to prevent blood clots in extended treatment after DCVT, leading to their gradual recovery, with recanalization of the deep venous system.　Conclusions　The clinical symptoms of DCVT patients are non-specific, and DCVT in the early stages is particularly hard to diagnose. Specific attention should be given to the specific imaging features which could help to diagnose DCVT. The DCVT patients will achieve a better outcome following timely anticoagulant treatment.

Key words: Intracranial deep venous thrombosis, 　Basal vein of Rosenthal, 　Internal cerebral vein, Vein of Galen, 　Straight sinus, 　Imaging, 　Treatment