Abstract:  Objective   The small incision sub-palmar aponeurotic transverse carpal ligament incision under the guidance of safe angle is a treatment of carpal tunnel syndrome. This article is aimed to discuss this treatment’s clinical therapeutic effect.   Methods    From June 2015 to June 2018, 105 cases (112 sides) of carpal tunnel syndrome were treated by small incision sub-palmar aponeurotic transverse carpal ligament incision under the guidance of safe angle. 14 sides had lysis of adventitia of median nerve under direct vision.  Results   All incisions had primary healing, the palm scars were mild, and no operative complications happened. We followed 112 sides after the surgery. The follow-up time was 6-24 months. Result showed that   according to Kelly classification, 93 sides were ranked to excellent, 15 were good and 4 were fair. The excellent and good rate was 93.1%.  Conclusions   Small incision sub-palmar aponeurotic transverse carpal ligament incision under the guidance of safe angle is one of the ideal minimal invasive operations to treat carpal tunnel syndrome. This operation is simple, safe and can meet the needs of carpal tunnel decompression and neurolysis  

Key words: Safe angle, 　Carpal tunnel syndrome, 　Mini-open, 　Carpal tunnel Release, 　Median nerve