Abstract: Objective　To evaluate the efficacy of CalliSpheres drug-loaded microsphere uterine artery embolization in the treatment of locally advanced cervical cancer.　Methods　Forty-eight patients (average age was 49 years old) with cervical cancer admitted to our department from February 2016 to September 2018 were randomly divided into two groups: normal microsphere uterine artery embolization + 24 cases of epirubicin uterine arterial infusion chemotherapy (group A); 24 cases of drug-loaded microspheres (epimycin) uterine artery chemoembolization (group B). Each group was treated with the same procedures three weeks apart, total two times. The reduction in bleeding was recorded, and tumor size changes were evaluated by CT, and bone marrow suppression and digestive tract reactions were analyzed.　Results　(1) Both groups of patients had reduced vaginal bleeding. The duration of postoperative bleeding in the conventional microsphere group was (6±1.5) days, and that in the drug-loaded microsphere group was (3±0.8) days, the difference was statistically significant (P<0.01). (2) Tumor reduction rate: The objective remission rate of the ordinary microsphere group was 83.8%, and that of the drug-loaded microsphere group was 95.8%. The difference was statistically significant (P<0.01). (3) Abdominal pain occurred in both groups. The VAS score of the general microsphere group was (8±2), and the VAS score of the drug-loaded microsphere group was (3±1). There were statistical difference in the VAS score (P<0.01). Myelosuppression occured only in the normal microsphere group.　Conclusions　CalliSpheres drug-loaded microspheres have higher tumor shrinkage rate for cervical cancer, shorter postoperative vaginal bleeding, no bone marrow suppression and controllable abdominal pain.

Key words: Cervical cancer, 　Chemoembolization, 　Embolization microspheres, 　CalliSpheres beads