长链非编码LncRNA-MEG3在激素性股骨头坏死中的表达及相关性研究

doi:10.13418/j.issn.1001-165x.2022.2.13

Abstract

Abstract: Objective To investigate the expression and significance of long non-coding RNA-MEG3(lncRNA-MEG3) in steroid-induced femoral head necrosis. Methods Real-time fluorescence quantitative PCR was used to detect the expression of lncRNA-MEG3 in femoral head tissues of patients with femoral neck fracture (30 cases) and femoral head and its adjacent tissues of patients with steroid-induced femoral head necrosis (30 pairs), and its clinical significance was analyzed. Results The content of lncRNA-MEG3 was the highest in the femoral head bone tissues with steroid-induced necrosis, its adjacent tissues was followed, and the lowest was the bone tissues of patients with femoral neck fracture, the difference was statistically significant (P<0.05). There was no significant difference in the ratio of gender and age(less than 60 years old or more than 60 years old) between the two groups(P>0.05). In the femoral head necrosis group, there was no significant difference in lncRNA-MEG3 content among patients taking different hormone types (meprednisone or dexamethasone) (P>0.05). In patients with different ARCO stages (stage Ⅲ orⅣ), the relative expression of lncRNA-MEG3 in stage IV was higher that of stage Ⅲ (P<0.05). Conclusions The expression of long non-coding RNA-MEG3 is closely related to steroid-induced femoral head necrosis, and its expression is related to ARCO stage of steroid-induced femoral head necrosis.

Key words: Long non-coding RNA; , , MEG3; , , Femoral head necrosis; , , Hormone

CLC Number:

R681.8

Cai Hao, Chen Chun. Expression and correlation of long non-coding lncRNA-MEG3 in steroid-induced femoral head necrosis[J]. Chinese Journal of Clinical Anatomy, 2022, 40(2): 187-191.

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Expression and correlation of long non-coding lncRNA-MEG3 in steroid-induced femoral head necrosis

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