基于网络药理学探究络石藤-牛膝药治疗关节炎的作用机制

doi:10.13418/j.issn.1001-165x.2022.5.12

Abstract

Abstract: Objective To analyze the potential mechanism of herb-pair “Trachelospermum jasminoides and Achyranthes bidentata” based on network pharmacology in Arthritis. Methods The effective components and target genes of “Trachelospermum jasminoides and Achyranthes bidentata” were screened by searching the pharmacological database platform of Chinese herbal medicine system (TCMSP). Setting “Arthritis” as the key word, human gene retrieval was performed in GeneCards database, NCBI gene database and OMIM database to obtain genes, which were related to Arthritis. The selected drug pair targets and disease targets were input into Venny 2.1 software to obtain common targets. The STRING database was used to construct PPI network, and the “herb-component-target-disease” network was constructed by Cytoscape. The gene ontology (GO) functional enrichment analysis and KEGG pathway analysis of key target genes were carried out by R language software. Results Totally, 9 compounds and 94 targets of Trachelospermum jasminoides were obtained from TCMSP, while 21 compounds and 205 targets got from Achyranthes bidentata. Venny mapping obtained 128 common targets, and a total of 5 gene clusters and 4 core genes were screened out from the STRING database to construct PPI network. The GO functional enrichment analysis showed that the herb-pair “Trachelospermum jasminoides and Achyranthes bidentata” involved 2329 biological processes, 150 molecular function correlations and 60 cell composition correlations. Through KEGG pathway enrichment analysis, “Trachelospermum jasminoides and Achyranthes bidentata” herb-pair in the treatment of Arthritis enriched a total of 154 signal pathways. Conclusions Based on network pharmacology, the possible mechanism of herb-pair “Trachelospermum jasminoides and Achyranthes bidentata” in the treatment of Arthritis was preliminarily verified from the aspects of active components, gene targets and signal pathways.

Key words: Trachelospermum jasminoides; , , Herb-pair; , Achyranthes bidentata; , , Arthritis; , , Network pharmacology

CLC Number:

R310.47

Pang Ting, Tang Qiulian, Chen Yong, Wei Jiangcun, Liang Cao, Wang Zhiqiang, He Huan, Zeng Chao. Mechanism of herb-pair Trachelospermum jasminoides and Achyranthes bidentata treating Arthritis based on network pharmacology[J]. Chinese Journal of Clinical Anatomy, 2022, 40(5): 569-574.

References 19

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Mechanism of herb-pair Trachelospermum jasminoides and Achyranthes bidentata treating Arthritis based on network pharmacology

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