Abstract: Objective    To explore the value of various influencing factors in predicting air enema failure in children with intussusception.    Methods    Clinical data of children with intussusception admitted to Wuhan Children's Hospital from January 2012 to December 2019 were retrospectively analyzed, including gender, age, duration of disease, paroxysmal crying or abdominal pain, bloody stool, vomiting, fever, diarrhea, abdominal mass, hospital stay, intestinal obstruction, intussusception position, intussusception type, and results of air enema and surgery treatment. Mann-Whitney U test or Chi-square test was used in univariate analysis. Independent influencing factors were determined by binary logistic regression analysis, and the value of various factors to predict the enema failure was analyzed by the AUC value of the ROC curve.   Results There were statistical differences in age, duration of disease ≥ 48h, paroxysmal crying or abdominal pain, bloody stool, vomiting, fever, diarrhea, abdominal mass, intestinal obstruction, intussusception located in the left colon and hospitalization time between the successful and failed groups (P<0.05). There was no statistical difference in the gender distribution between the two groups (P>0.05). Regression analysis result showed that age was a protective factor for enema failure, while the duration of disease≥48 h, blood stool, vomiting, fever, abdominal mass, intestinal obstruction, and intussusception in the left colon were risk factors. ROC analysis result showed that intussusception located in the left colon, age, blood stool, and intestinal obstruction had certain predictive accuracy; and the best cut-off point for age was 10.5 months. Joint prediction with intestinal obstruction, bloody stool, age, and intussusception located in the left colon could improve the accuracy. Conclusions   Age≤10.5 months, blood stool, intestinal obstruction, and intussusception located in the left colon have certain accuracy in predicting enema failure, and the accuracy will be higher when joint prediction.

Key words: Pediatric intussusception,  ,  ,  , Air enema,  ,  ,  , Enema failure, Influencing factors, Prediction