苦参凝胶对银屑病大鼠皮肤损伤组织病理学及IL-6、PAR-2水平的影响

doi:10.13418/j.issn.1001-165x.2023.1.13

Abstract

Abstract: Objective To study the effects of Kushen gel on histopathology, interleukin -6 (IL-6) and protease activated receptor -2 (PAR-2) levels in psoriatic rats. Methods Sixty Wistar rats were divided into a control group, a model group, a vitamin A acid group, Kushen gelatin high, medium and low dose groups, 10 rats in each group. The general condition, pathological changes of skin lesions, inflammatory cell infiltration score, Baker score and levels of IL-6 and PAR-2 in serum and skin lesions were observed in each group. Results The scales and erythema on the back of rats in each group treated with vitamin A acid and Sophora flavescens gel were alleviated than those in model group. The symptom relief degree of Kushen gel group was better than that of vitamin A acid group. The pathological changes of the skin lesions of rats in different doses of vitamin A acid group and Sophora flavescens gel group were improved to a certain extent than those in model group. The improvement of Kushen gel medium and high dose group was better than that of vitamin A acid group. The inflammatory cell infiltration score, Baker score, IL-6 and PAR-2 levels in the model group were significantly higher than those in the control group (P<0.05). The inflammatory cell infiltration score, Baker score, IL-6 and PAR-2 levels in each treatment group were significantly lower than those in the model group (P<0.05). The inflammatory cell infiltration score, Baker score, IL-6 and PAR-2 levels in the middle and high dose group were significantly lower than those in the A acid group (P<0.05). Conclusions Kushen gel can improve histopathology and IL-6 and PAR-2 levels in psoriatic rats.

Key words: Sophora flavescens gel; , , Psoriasis; , , rat; , , Interleukin -6; , , Protease activated receptor -2

CLC Number:

R751.05

Xiong Yang, Chen Yan, Wei Dong, Zhang Qin, Cheng Maojie, Song Qi. Effects of Sophora flavescens gel on histopathology, IL-6 and PAR-2 levels in psoriatic rats[J]. Chinese Journal of Clinical Anatomy, 2023, 41(1): 72-76.

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Effects of Sophora flavescens gel on histopathology, IL-6 and PAR-2 levels in psoriatic rats

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