Abstract: Objective　To investigate the factors influencing early pregnancy loss following husband intrauterine insemination (IUI).    Methods    A retrospective analysis was conducted on the clinical data of 426 IUI cycles from 405 couples who tested positive for HCG and received IUI treatment at our center between January 2015 and December 2023. Based on pregnancy outcomes, the patients were divided into two groups: the early pregnancy loss group (n=85) and the ongoing pregnancy group (n=341). Basic patient characteristics, endometrial thickness on the day of HCG administration, and semen parameters were compared between the two groups. Univariate and multivariate analyses were performed to identify factors associated with early pregnancy loss.    Results    The early pregnancy loss rate in the reviewed cycle was about 19.95% (85/426). Univariate analysis showed there were no significant differences in female age, BMI, basal FSH, duration of infertility, total motile sperm count after processing, treatment protocol, number of cycles, male smoking status, normal sperm morphology rate, duration of abstinence, male factors, PCOS, and pelvic tubal factors (P>0.05). There were significant differences in the FSH/LH ratio, type of infertility, and endometrial thickness on the day of HCG administration between the two groups (P<0.05). Multivariate regression indicated that FSH/LH ratio (P<0.05), type of infertility (P<0.05) and PCOS (P<0.05) were independent factors influencing early pregnancy loss in IUI.    Conclusions    FSH/LH ratio≥2, type of infertility, and PCOS are significant factors influencing early pregnancy loss in intrauterine insemination.  

Key words: Intrauterine insemination, 　Early pregnancy loss, 　Miscarriage, 　Influencing factors