Chinese Journal Of Clinical Anatomy ›› 2012, Vol. 30 ›› Issue (1): 70-73.

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Effects of secretoneurin on VCAM, MCP-1 and Ki67 expression in blood vessel smooth muscle cell

WU Xiao-qiong1, LUO Ming-ying1, ZHU Wu2, YANG Bao-lin1, LUO Hua1, CAI Wei-jun2   

  1. 1.Department of Anatomy & Neurobiology, 2.Department of Histology & Embryology, Xiangya School of Medicine, Central South University, Changsha 410003,China
  • Received:2010-12-30 Online:2012-01-25 Published:2012-02-03

Abstract:

Objective To investigate the effect of secretoneurin on expression of VCAM, MCP-1 and Ki67 in blood vessel smooth muscle cells (VSMCs). Methods VSMCs culture from adult mouse thoracic aorta were randomly divided into normal control and SN experiment. The expression of VCAM, MCP-1 and Ki67 were detected by immunofluorescene. The result was viewed and recorded under confocal instrument,and the data were processed with EZ-C1 3.70 FreeViewer system.Results The expression of VCAM, MCP-1 and Ki67 in VSMCs treated with SN about 24h were significantlty increased compared to that of normal control (P<0.05). Conclusions SN up-regulate the expression of VCAM, MCP-1,and promote the proliferation of vascular smooth muscle cells.

Key words: Secretoneurin, Vascular smooth muscle cells, Proliferation, Vascular cell adhesion molecule, Monocyte chemoattractant protein

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