兔蛛网膜下腔出血后大脑深静脉的磁共振观察

Abstract

Abstract:

Objective　To build a model of subarachnoid hemorrhage (SAH) in rabbit and observe the changes of diameters of the deep cerebral veins after SAH, in order to provide a new theoretical basis for the occurrence and therapy of vasospasm after SAH.　Methods　A total of 38 New Zealand rabbits were randomly divided into two groups: normal saline (NS) group (n=5), and SAH group (n=33). The SAH animals were made by infusing autologous arterial blood into the cisterna magna twice, and the NS group had saline instead of blood. The behavior and neurological function of animals in SAH group (4 rabbits) and in NS group (2 rabbits) were observed. Another 14 SAH rabbits were sacrificed and observed by microscopic anatomy. MR scan was performed 1 day before making model and 5 days after making model again in other rabbits. Results Microscopic anatomy showed that coagulated blood was obviously found around the ventral surface of brain stem, lateral ventricles and quadrigeminal cistern. In NS group, no statistical difference was found (P>0.05) among the diameters of internal cerebral vein (ICV), basilar vein (BV) and great cerebral vein (GV) before and after making model. In SAH group, the diameters of ICV, BV, GV were separately (0.57±0.13)mm, (0.38±0.08)mm, (1.33±0.31)mm before making model. However, the diameters of them were (0.42±0.08)mm, (0.25±0.12)mm, and (1.26±0.31)mm at 5 days after making model, which were significantly different compared to that at 0 day. Conclusions Various vasospasm of deep cerebral veins after SAH will be developed.

Key words: Subarachnoid hemorrhage, Cerebral vasospasm, Deep cerebral veins, Magenatic resonance imaging

CLC Number:

R322.8

DAI Zong-Fei, DENG Xue-Fei, ZHANG Zi-Han, SHU You-Zhi, ZHANG Yu, LI Da-Ku, JIA Xiang-Wei, MO Zi, HAN Hui. MRI study of deep cerebral veins after subarachniod hemorrhage in rabbits[J]. Chinese Journal Of Clinical Anatomy, 2012, 30(2): 176-180.

References

[1] Crowley RW, Medel R, Kassell NF, et al. New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage
[J]. Drug Discov Today, 2008, 13(56):254-260.

[2] Treggiari-Venzi MM, Suter PM, Romand JA. Review of medical prevention of vasospasm after aneurysmal subarachnoid hemorrhage: a problem of neurointensive care
[J]. Neurosurgery, 200l, 48(2):249-261.

[3] Shimoda M, Takeuchi M, Tominaga J, et a1. Asymptomatic versus symptomatic infarcts from vasospasm in patients with subarachnoid hemorrhage: serial magnetic resonance imaging
[J]. Neurosurgery, 200l, 49(6):1341-1350.

[4] 焦轶,庞刚,邓雪飞. 人脑桥静脉平滑肌细胞α-肌动蛋白的表达
[J]. 解剖学杂志, 2010, 33(5):598-601.

[5] Liszczak TM , Varsos VG, Black PM ,et al. Cerebral arterial constriction after experimental subarachnoid hemorrhage is associated with blood components within the arterial wall
[J]. J Neurosurg, 1983, 58(1):18-26.

[6] Plauta RM, Hansen SJ, dreier J, et al. Cerebral vasospasm following subarachnoid hemorrhage:time for a new world of thought
[J]. Neurol res, 2009, 31(2):151-158.

[7] Rosengart AJ, Schultheiss KE, Tolentino J, et al. Prognostic factors for outcome in patients with aneurismal subarachnoid hemorrhage
[J]. Stoke, 2007, 38(8):2315-2321.

[8] Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage
[J]. Stroke, 2010, 41(8):519-536.

[9] Vergouwen MD, Ilodigwe D, Macdonald RL. Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
[J]. Stroke, 2011, 42(4):924-929.

[10] Tang WH, Chen Z, Liu Z, et al. The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo
[J]. Neurol Res, 2008, 30(6):571-580.

[11] Tsurutani H, Ohkuma H, Suzuki S. Effects of thrombin inhibitor on thrombin -related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model
[J]. Stroke, 2003, 34(6):1497-1500.

[12] Zubkov AY, McBane RD, Brown RD, et al. Brain lesions in cerebral venous sinus thrombosis
[J]. Stroke, 2009, 40(4):1509-1511.

[13] Bederson JB, Connolly ES, Batjer HH, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association
[J]. Stroke, 2009, 40(3):994-1025.

MRI study of deep cerebral veins after subarachniod hemorrhage in rabbits

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 1

Metrics

Comments

Recommended 0