内窥镜腰椎间盘切除术与开放式手术组织伤害的比较

Abstract

Abstract:

Objective　 The purpose of this study is to compare the overall effects of surgical trauma and surgical results resulting from PELD and OD.　Methods　The patients were randomly allocated into two groups, the PELD and OD groups. Each group contained 10 patients. Blood loss, hospital stay, and skin incision size will be recorded in these two groups. In this study, a quantitative comparison will be performed through analysis of patient's systemic cytokines, CPK and CRP response. An enzyme-linked immunosorbent assay (ELISA) was used for serum levels of Interleukin-1beta(IL-1), Interleukin-6 (IL-6), and Interleukin-8 (IL-8), Interleukin- 10(IL-10) and were measured before surgery and at 1,6,12 ,24 and 48 hours after surgery. Serum C-reactive protein (CRP) and creatine phosphokinase (CPK) were measured at the same time interval.　Results The overall results showed PELD group had less blood loss ( P＜0.01), less hospital stay(P＜0.01), less skin incision size(P＜0.01) than OD group. Using the modified MacNab criteria, the clinical outcomes were 90% in PELD and OD group at the postoperative 6-month follow up. CRP、 CPK、IL-6 level showed significant difference at 24 hours and 48 hours between the two groups (P＜0.01). The systemic IL-6, CRP and CPK were significantly less following PELD than OD.　Conclusion　PELD offers a similar short-term clinical outcome，with smaller incision，less tissue trauma and quicker recovery than OD.

Key words: Percutance, Endoscopic lumbar discectomy, Open discectomy, Lumbar disc herniation, Systemic cytokines

CLC Number:

R681.5

PAN Lei, YIN Qing-Shui. Comparison of tissue damages caused by endoscopic lumbar discectomy and open lumbar discectomy[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(5): 596-599.

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Comparison of tissue damages caused by endoscopic lumbar discectomy and open lumbar discectomy

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