The relationship between the size, shape of corpus callosum and gestational age in neonatal infants
LIU Rui-Ge, LIU Fang, LIN Chang-Jun, LI Jian-Yang, TUN Xiu-Fang
Chinese Journal of Clinical Anatomy ›› 2014, Vol. 32 ›› Issue (1) : 31-35.
The relationship between the size, shape of corpus callosum and gestational age in neonatal infants
Objective The aim of this study was to study the pattern of callosal development by MRI to investigate neonatal corpus callosum size and shape in different gestational ages and to analyze the relationship between the area, eccentricity ratio and posterior skew of neonatal corpus callosum and gestational age, so that reference for early evaluation of the development of brain can be provided. Method 286 eligible high field brain MR images of neonates were selected. All corpus callosums were sketched in the MR images. And then, all data were analyzed by Image Processing Function of MATLAB R2010a. Corpus callosum area, eccentricity ratio and skew in 286 neonates were obtained and analyzed statistically, respectively. Result Pearson correlation analysis indicated the positive linear correlation between the corpus callosum area and gestational age (r=0.61, P<0.001). The corpus callosum area formed a quadratic curve with the gestational age, which was Y=0.132X2-6.179X+141.759(R2=0.37, P＜0.001). Spearman rank correlation analysis indicated the positive linear correlation between the eccentricity ratio of corpus callosum and gestational age (r=0.25，P＜0.001). The eccentricity ratio of corpus callosum formed a linear equation with the gestational age, which was Y=0.009X+0.319 (R2=0.07，P＜0.001). Pearson correlation analysis indicated the positive linear correlation between the skew of posterior corpus callosum and gestational age (r=0.27，P＜0.001). The skew of posterior corpus callosum formed a linear equation with the gestational age, which was Y=0.005X+0.349 (R2=0.07，P＜0.001). Conclusion The results of this study suggest that the smaller the gestational age of the newborn, the smaller and circular the corpus callosum.
Brain / Corpus callosum / Magnetic resonance imaging / Neonate / Gestational age
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