Dimebon对小鼠中型多棘神经元NMDA激活电流的影响

doi:10.13418/j.issn.1001-165x.2015

Abstract

Abstract:

Objective Dimebon is an antihistamine compound which has been proposed to treat neurodegenerative disorders, but the mechanism remain elusive. To explore Dimebon effection on Alzheimer's disease and Huntington's disease. Method Membrane currents were measured by using whole cell patch clamp techniques. the influence ofdifferent concentration of Dimebon on NMDA -activated currents in primary Medium Spiny Striatal Neuronal cultures (MSN) from wild type (WT) mice were studied. Results 1~50 μmol/L Dimebon inhibited NMDA activated currents, but 0.1~0.5μmol/L increased NMDA activated currents. Conclusion Dimebon has dual function on NMDA receptors.

Key words: Dimebon, , Medium spiny striatal neurons, NMDA receptor

CLC Number:

R338

HU Xiao-Li, LI Qin, SONG Lou, Ilya Bezprozvanny. Effect of dimebon on NMDA-activated current in mice medium spiny neuron [J]. Chinese Journal Of Clinical Anatomy, 2015, 33(1): 89-92.

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Effect of dimebon on NMDA-activated current in mice medium spiny neuron

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