阿尔茨海默病患者松果体MRI研究

doi:10.13418/j.issn.1001-165x.2016.04.005

Abstract

Abstract:

Objective　To observe morphological changes of pineal gland in the process of Alzheimer' s disease (AD) by MRI. 　Methods　According to the process of AD, brain MRI images of 24 cases, 18 cases, 16 cases and 20 cases from the normal control group, MCI group, mild AD group and moderate-severe AD group, respectively. Length, width, height and volume of the pineal gland had been measured, the change trend of the measurement between each group was then analyzed.　Results　The standardized height of pineal gland had an increase in the MCI and mild AD compared with NC group （P＜0.05）and had a reduction in the moderate-severe AD compared with the MCI and mild AD（P＜0.05）; The standardized length, width and volume of pineal gland had no significant change in the MCI, mild AD and moderate-severe AD compared with NC group（P＞0.05），but had a reduction in the moderate-severe AD compared with MCI（P＜0.05）.　Conclusion　The height of pineal gland has a growth tendency at the incipient stage of the process of AD, and then will shrink. Measurement the height of pineal gland by MRI was helpful in the diagnosis of MCI and mild AD patients.

Key words: Alzheimer' s disease, Magnetic resonance imaging, Pineal gland

DENG Ling，QIAN Xue-hua，GUO yi，XU Yu-yu，Lü Fa-jin. The pineal gland MRI study in Alzheimer's patients[J]. Chinese Journal Of Clinical Anatomy, 2016, 34(4): 378-382.

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The pineal gland MRI study in Alzheimer's patients

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